Enhancing the Versatility of Polyethylene Terephthalate (PET) Through Strategic Biomolecular Functionalization

As biocatalytic strategies for PET recycling reach maturation, insights gained from PET hydrolase research can be leveraged to inform the design of proteins and surface-functionalization strategies that promote stable association of functional proteins with PET surfaces, enabling the development of functional protein-plastic hybrid materials. Herein, we examine recent developments in biofunctionalization strategies of PET and related materials, with a focus on chemical biology approaches that offer more precise control of the orientation of proteins on PET and related materials. Biophysical insights from protein-polymer interface chemistry studies can inform protein selection, design, and engineering approaches to minimize denaturation and maximize function of proteins upon attachment to surfaces. Finally, we highlight applications of protein-functionalized PET and related synthetic polymers, including for biomedical applications and scalable biocatalysis, showcasing the potential of integrating biological activity into durable synthetic polymers.