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GeneInsight: Condensing gene set knowledge via language models
Wee Loong Chin1,2,3, Kevin Chen3, Timo Lassmann3
1National Centre for Asbestos-Related Diseases, University of Western Australia, Perth, Western Australia, Australia.
Abstract:
Gene set analysis often returns extensive annotations from multiple sources, requiring manual effort to identify coherent biological themes. We developed GeneInsight, an AI-powered tool that automates this by retrieving functional annotations from STRING-DB, clustering semantically related terms using sentence embeddings, and generating thematic summaries via large language model prompting. This enables researchers to identify biological themes that may be obscured when annotation sources are examined separately.
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