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Feasibility, Usability, and Acceptability of an Adaptive Mobile Health Medication Adherence Intervention for Youth:
Caitlin S Sayegh1,2, Shinyi Wu3,4, Stephanie Lopez5
1Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
JMIR Formative Research
|August 5, 2026
Summary
This study developed an adaptive mobile health intervention to improve medication adherence in adolescents and young adults with chronic conditions. While the intervention showed promise and high usability, further refinement is needed for optimal effectiveness.
Area of Science:
- Digital Health
- Adolescent Medicine
- Chronic Disease Management
Background:
- Adolescents and young adults with chronic conditions face challenges with daily oral medication adherence.
- Mobile health (mHealth) interventions offer scalable solutions to support medication adherence in this population.
Purpose of the Study:
- To design an adaptive medication adherence mHealth intervention (Adaptive Cell Phone Support) using iterative feedback.
- To evaluate the feasibility, usability, and acceptability of the intervention through user testing.
- To explore changes in self-reported medication adherence during a field trial.
Main Methods:
- Human-centered design and collaboration with a patient advisory board.
- Iterative design cycles with usability testing involving 22 adolescents and young adults (aged 15-20).
- Mixed-methods data collection including questionnaires, interviews, and a 3-week field trial.
Main Results:
- The intervention demonstrated high usability and acceptability ratings across design iterations.
- Participants found the mHealth tool simple, convenient, and helpful for medication accountability.
- A significant increase in the percentage of time taking medications was observed during the field trial.
Conclusions:
- The adaptive mHealth intervention shows potential for improving medication adherence in young people.
- Continued refinement based on user feedback is essential for optimizing the intervention's effectiveness.
- Early community engagement in digital health tool development enhances feasibility and acceptability.
