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Updated: Aug 7, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Risk factors for the progression to epilepsy following acute-phase autoimmune encephalitis with seizures: A
Qianqian Liu1, Lang Shen2, Xia Cai3
1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers' Hospital, Liuzhou, China.
Objective:
To investigate the clinical features and risk factors for progression from acute-phase autoimmune encephalitis (AE) with epileptic seizures to autoimmune encephalitis-associated epilepsy (AEAE).
Methods:
We retrospectively analyzed clinical data from patients with acute-phase autoimmune encephalitis presenting with seizures between January 2016 and July 2024 at two clinical centers. Following a minimum follow-up of one year, patients were categorized into the ASSAE group or the AEAE group. Multivariable logistic regression identified independent predictors. Model performance was assessed by ROC analysis with bootstrap validation (B = 1000) and calibration testing.
Results:
32 patients (22.9%) progressed to AEAE. Multivariable logistic regression identified symptom of prodromal infection as a protective factor (OR: 0.336, 95% CI: 0.131-0.862), while the number of ASMs at discharge was identified as a significant clinical indicator of AEAE development (OR: 2.854, 95% CI: 1.551-5.255). The model demonstrated good discrimination (bootstrap AUC: 0.766, 95% CI: 0.684-0.841) and excellent calibration (Hosmer-Lemeshow P = 0.849).
Conclusion:
Among patients with acute-phase AE and seizures, the number of ASMs at discharge and the absence of prodromal infection symptom are probable clinical indicators for predicting AEAE. These findings may facilitate early risk stratification and optimize management strategies for patients with AE-related seizures.
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