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CD30 expression in diffuse large B-cell lymphoma and primary mediastinal lymphoma: frequency, association with
Marcelo Bellesso1, Ibere Cauduro Soares1, Frederico Rafael Moreira1
1Universidade de Sao Paulo Instituto do Cancer do Estado de Sao Paulo, São Paulo, SP, Brazil.
Introduction:
CD30 expression has been studied as a prognostic and therapeutic biomarker in diffuse large B-cell lymphoma not otherwise specified (DLBCL-NOS) and primary mediastinal B-cell lymphoma (PMBCL). This study evaluated the frequency of CD30 expression, its association with National Comprehensive Cancer Network International Prognostic Index and cell of origin and impact prognosis.
Methods:
This retrospective cohort study included patients diagnosed with DLBCL or PMBCL between 2009 and 2016 at the Instituto do Câncer do Estado de São Paulo. Adult patients who received curative-intent treatment and had available histopathological material were included. CD30-positive cases were tested for Epstein-Barr virus by in situ hybridization: positive cases were excluded.
Results:
A total of 301 patients were analyzed (279 DLBCL and 22 PMBCL). CD30 positivity was found in 19.6% of cases (19% in DLBCL and 27.3% in PMBCL). Among the CD30-positive cases, nodal biopsies were more frequent (62.7%) than extranodal (37.3%) (p = 0.03). No significant association was found between CD30 expression and the National Comprehensive Cancer Network International Prognostic Index or cell of origin (germinal center B-cell-like vs. non-germinal center B-cell-like). CD30 expression did not impact overall survival (p = 0.22) or progression-free survival (p = 0.42). In the DLBCL subgroup, CD30 expression also showed no significant effect on overall survival (p = 0.35) or progression-free survival (p = 0.70).
Conclusion:
This is the first Brazilian and Latin American study to assess CD30 expression in DLBCL and PMBCL. CD30 expression was observed in 19.6% of cases, more commonly in nodal biopsies, but showed no prognostic significance.