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Published on: November 4, 2010
Is Remission a Meaningful Outcome in Asthma?
Jason Moraczewski1, Leonard B Bacharier1
1Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center, Nashville, TN, USA.
Summary
Asthma management is shifting towards proactive care, aiming for disease control and remission using biologics. Further research is needed to standardize remission definitions and explore disease modification potential.
Area of Science:
- Pulmonology
- Immunology
- Pharmacology
Background:
- Current asthma management focuses on symptom relief and exacerbation control.
- Asthma management is evolving towards a proactive approach for full disease control.
- On-treatment clinical remission and disease modification are emerging goals in asthma care.
Purpose of the Study:
- To explore the shift in asthma management principles.
- To evaluate the role of biologic therapies and allergen immunotherapy in achieving asthma remission.
- To discuss the potential for biologics in inducing remission and disease modification.
Main Methods:
- Review of current asthma management principles.
- Analysis of emerging evidence on biologic therapies and allergen immunotherapy.
- Discussion on the need for standardized remission definitions and validation.
Main Results:
- Biologic therapies targeting type 2 inflammation show promise for achieving on-treatment remission.
- Emerging evidence suggests biologics may induce remission and structural disease modification.
- Standardized and validated definitions for asthma remission are needed, incorporating biomarkers and diverse populations.
Conclusions:
- Asthma care is transitioning to a proactive model focused on remission and disease modification.
- Biologics offer potential for achieving remission and modifying asthma's structural progression.
- Further studies are required to establish remission and disease modification as primary endpoints in asthma treatment.
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