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Cancer Type-Specific Risks of Retinal Vascular Occlusion: A Nationwide Population-Based Study
Myung Soo Chang1, Seung Won Lee2, Gahyun Kim2
1Department of Ophthalmology, Institute of Vision Research, College of Medicine, Yonsei University, Severance Hospital, Seoul, Republic of Korea.
Ophthalmology. Retina
|August 5, 2026
Summary
Cancer survivors face higher risks of retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Hematologic cancers elevate RAO risk, while eye cancers are linked to increased RVO risk.
Area of Science:
- Ophthalmology
- Oncology
- Epidemiology
Background:
- Cancer survivors experience increased risks for various health complications.
- Retinal vascular occlusions, including RAO and RVO, are serious conditions.
- Understanding these risks in cancer survivors is crucial for long-term care.
Purpose of the Study:
- To determine the incidence and risk of RAO and RVO in cancer survivors.
- To analyze these risks across different anatomical cancer subgroups.
- To compare risks in cancer survivors to the general population.
Main Methods:
- A retrospective, nationwide, population-based cohort study.
- Included 462,185 cancer patients diagnosed between 2011-2022 in South Korea.
- Used Korean National Health Insurance Sharing Service data, classifying cancers into 15 subgroups.
Main Results:
- Cancer survivors showed increased risks for RAO (SIR 1.27) and RVO (SIR 1.15) compared to the general population.
- Hematologic malignancies had the highest RAO risk (SIR 2.50) and elevated RVO risk (SIR 1.52).
- Eye and adnexa cancers were most strongly associated with RVO risk (SIR 3.03).
Conclusions:
- Cancer survivors have significantly elevated risks for both RAO and RVO.
- Hematologic malignancies are linked to higher risks of both conditions.
- RVO is a notable vascular complication in cancer survivorship requiring further investigation.
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