ADJUNCTIVE MANUKA HONEY ORAL RINSE IN NONSURGICAL PERIODONTAL THERAPY FOR HEMODIALYSIS PATIENTS: A RANDOMIZED...

Area of Science:

• Periodontology
• Nephrology
• Biomaterials Science

Background:

• Periodontitis is common in hemodialysis patients, increasing their risk for systemic complications.
• Nonsurgical periodontal therapy (NSPT) is a standard treatment for periodontitis.
• Manuka honey possesses antimicrobial and anti-inflammatory properties.

Purpose of the Study:

• To assess the clinical effectiveness of Manuka honey oral rinse as an adjunct to NSPT in hemodialysis patients with periodontitis.
• To evaluate changes in periodontal parameters, inflammatory biomarkers, and oral health-related quality of life.

Main Methods:

• A randomized, blinded, controlled trial involving 140 hemodialysis patients with Stage III periodontitis.
• Participants received either NSPT with Manuka honey rinse or NSPT with saline rinse.
• Clinical attachment level (CAL), probing depth (PD), bleeding on probing (BOP), plaque index (PI), gingival crevicular fluid FGF23, serum CRP, and OHIP-14 were assessed.

Main Results:

• The Manuka honey group showed significantly greater improvements in CAL, PD, and BOP compared to the saline group at 6 months.
• Reductions in gingival crevicular fluid FGF23 and serum CRP levels were significantly greater in the Manuka honey group.
• Oral health-related quality of life (OHIP-14) scores improved significantly more in the Manuka honey group.

Conclusions:

• Adjunctive Manuka honey oral rinse may offer additional benefits to NSPT for periodontitis in hemodialysis patients.
• The findings suggest a potential supportive role for Manuka honey in managing periodontal disease in medically compromised individuals.
• Further studies are required to validate these findings and assess systemic clinical outcomes.