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Updated: Aug 7, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

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Published on: July 17, 2019

HuR degradation reveals dependencies in BRAF-driven cancers

Ivan R Siordia1, Jonathan R Brody1, Dan A Dixon2

  • 1Department of Surgery, Oregon Health & Science University, Portland, OR, USA; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA; Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.

Trends in Cancer
|August 5, 2026
PubMed
Summary

Researchers discovered a molecular glue that degrades HuR, a challenging RNA-binding protein target. This breakthrough suppresses BRAF-mutant colorectal cancer, offering a new therapeutic strategy for specific cancers.

Keywords:
BRAFHuRcolorectal cancermolecular glue

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