Related Experiment Video
Updated: Aug 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Ru(II)-Catalyzed Cascade Regioselective C-7 and C-8 Diamidation of Isoquinolinones Using Dioxazolones
Ravichandran Manikandan1, Annamalai Pratheepkumar1
1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Abstract:
In this study, we disclose an unprecedented ruthenium-catalyzed selective C-7 and C-8 diamidation of isoquinolinones via weak chelation assistance, employing dioxazolones as an efficient amidating agent. Significantly, in this reaction, dual C─H bonds were functionalized in one pot, enabling isoquinolinones embedded in diamidated scaffolds with high efficiency. The developed protocol enables the efficient synthesis of a broad array of diamidated isoquinolinones derivativities in excellent yields, including pharmaceutically relevant motifs derived from carboxylic acid and fatty acid containing dioxazolones. The resulting products exhibit excellent compatibility toward further synthetic diversification.
Related Concept Videos
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Acid-Catalyzed Ring-Opening of Epoxides
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)