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Updated: Aug 7, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Structural Determinants and the Limits of the Clinical Model in Periodontal Disease
Fábio R M Leite1, Gustavo G Nascimento1, Marco A Peres2,3
1School of Dentistry, University of Utah, Salt Lake City, Utah, USA.
Background:
Periodontitis remains one of the most prevalent chronic diseases worldwide and is strongly socially patterned. However, contemporary disease classifications and guideline-based management largely emphasise individualised, clinically intensive, long-term maintenance approaches. Whether these models are feasible, equitable, or sustainable when applied at the population level has received little attention.
Methods:
We synthesised evidence from global and national epidemiological studies, health systems research, clinical practice guidelines, and health policy analyses to examine the implications of current periodontitis classifications and care models for service demand, workforce capacity, equity, and universal health coverage. We developed a conceptual framework linking disease definitions, recommended care intensity, and health system constraints.
Results:
Current periodontitis classifications and maintenance-oriented care recommendations generate levels of service demand that substantially exceed the capacity of most oral health systems. This creates a feasibility paradox whereby increasingly comprehensive disease definitions and intensive maintenance schedules lead to implicit rationing of care and socially patterned access, disproportionately disadvantaging populations already at highest risk. The prevailing clinical paradigm also places limited emphasis on structural determinants of disease, population prevention, and value-based allocation of resources.
Conclusions:
A population-oriented reorientation of periodontal care is needed. We propose a framework that prioritises documented disease progression, risk of harm, and person-centred outcomes; aligns treatment intensity with expected benefit through risk-based and value-oriented approaches; and explicitly incorporates health system capacity together with the structural and commercial determinants of health. Moving beyond maintenance-for-all models toward feasible, equitable, and system-aware strategies is essential to reducing the population burden of periodontitis and advancing universal health coverage.
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