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Bioinspired Integrated MgH2 Hydrogel Synergistically Modulates the Osteo-Immune Microenvironment for Enhanced Bone
Rui Huang1, Zhonghua Yang2, Miao Wang1,3,4
1State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
Journal of Biomedical Materials Research. Part A
|August 6, 2026
Summary
This study introduces a novel magnesium hydride-gelatin methacryloyl composite for bone regeneration. It achieves sustained release of magnesium ions and hydrogen gas to enhance osteogenesis and modulate the immune microenvironment.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Magnesium-based biomaterials offer biocompatibility and osteogenic potential for bone regeneration.
- Rapid degradation limits their clinical application.
- Developing composites with controlled degradation and enhanced functionality is crucial.
Purpose of the Study:
- To develop a magnesium hydride-gelatin methacryloyl (MgH2-GelMA) composite for enhanced bone regeneration.
- To achieve sustained release of magnesium ions (Mg2+) and hydrogen gas (H2).
- To investigate the synergistic ion-gas mechanism in modulating the immune microenvironment and promoting osteogenesis.
Main Methods:
- Coating magnesium hydride microcrystals with silica to control degradation.
- Embedding coated particles within a gelatin methacryloyl (GelMA) hydrogel matrix.
- Evaluating the co-release of Mg2+ and H2, and their effects on bone marrow mesenchymal stem cells (BMSCs) and bone marrow-derived macrophages (BMDMs).
Main Results:
- The MgH2-GelMA composite demonstrated sustained release of Mg2+ and H2.
- Released Mg2+ promoted BMSC differentiation into osteoblasts, accelerating osteogenesis.
- Synergistic action of Mg2+ and H2 induced anti-inflammatory macrophage polarization, creating a pro-regenerative niche.
Conclusions:
- The developed MgH2-GelMA composite offers a promising strategy for bone regeneration by actively modulating the local microenvironment.
- A novel ion-gas synergistic mechanism was elucidated, enhancing osteogenesis and immune modulation.
- This work provides a foundation for developing advanced artificial bone materials that transition from passive replacement to active regeneration.
