The (European) protein homeostasis network

Proteostasis, the cellular network that governs protein synthesis, folding, trafficking, and degradation, is essential for maintaining cellular and organismal homeostasis. This review series highlights the breadth and impact of European research in the field of proteostasis, spanning fundamental mechanisms, organelle-specific quality control pathways, and emerging therapeutic opportunities. Contributions from leading laboratories across Europe examine key components of the proteostasis network, including translational regulation, molecular chaperones, ubiquitin-dependent protein degradation, organelle communication, and adaptive stress responses. Particular emphasis is placed on proteostasis mechanisms operating within the endoplasmic reticulum and mitochondria as well as on their roles in aging, inflammation, neurodegeneration, and other human diseases. The series also showcases the collaborative efforts that have strengthened the European proteostasis community through major networking initiatives and training programs. Together, these articles provide a comprehensive overview of current advances in proteostasis research and underscore its growing importance as a framework for understanding cellular adaptation and developing innovative therapeutic strategies.