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Updated: Aug 7, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

Protective Effects of Donkey Milk-Derived Exosomes Against UVB-Induced Skin Photoaging via Regulation of DNA Damage

Jie Yu1, Jinni Sun1, Jie Cheng1

  • 1Dong-E E-Jiao Co. Ltd, Liaocheng, Shandong, China.

Biomed Research International
|August 6, 2026
PubMed

Insights

Donkey milk-derived exosomes (DM-Exos) show promise in protecting skin from UVB damage. These exosomes reduce cellular senescence and DNA damage, offering a natural approach to combat skin aging.

Area of Science:

  • Dermatology
  • Biotechnology
  • Molecular Biology

Background:

  • UVB radiation accelerates skin photoaging, causing DNA damage and cellular senescence.
  • Natural interventions are sought to mitigate UVB-induced skin aging effects.

Purpose of the Study:

  • To investigate the protective effects of donkey milk-derived exosomes (DM-Exos) against UVB-induced skin aging.
  • To elucidate the underlying mechanisms of DM-Exos in preventing skin aging.

Main Methods:

  • In vitro skin cell models and in vivo mouse models were used.
  • Assessed cellular senescence markers (β-galactosidase activity, senescence-associated genes).
  • Measured reactive oxygen species (ROS) production and DNA damage markers (γ-H2AX, 8-OHdG).
  • Performed transcriptomic analysis and qPCR validation.

Main Results:

  • DM-Exos significantly reduced UVB-induced cellular senescence and ROS production.
  • DM-Exos attenuated DNA damage markers in vitro and in vivo.
  • Transcriptomic analysis revealed DM-Exos modulated key aging-related pathways.

Conclusions:

  • Donkey milk-derived exosomes demonstrate significant protective potential against UVB-induced skin aging.
  • DM-Exos offer a promising natural strategy for maintaining skin health and preventing photoaging.
Keywords:
DNA damageUVBdonkey milk-derived exosomesphotoagingsenescence

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