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Δ9-THC Promotes Profibrotic Cell States In Vitro and Impairs Vascular Function In Vivo

Nerea Jimenez-Tellez1, Francesca Vacante1, Themistoklis M Tsarouchas2

  • 1Stanford Cardiovascular Institute (N.J.-T., F.V., C.J., J.C.W.), Stanford University School of Medicine, CA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|August 6, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
actinscardiovascular diseasescell proliferationfibroblastsvascular remodeling

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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...