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Updated: Aug 7, 2026

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Virtual Reality Experiments with Physiological Measures
Published on: August 29, 2018
Comprehensive Assessment of Physiological and Psychological Responses to Virtual Reality Experiences
Valentin Fauveau1, Anastasia K Filimonov2, Renata Pyzik1
1Biomedical Engineering and Imaging Institute (BMEII), Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Journal of Medical Extended Reality
|August 6, 2026
Summary
Virtual reality (VR) effectively modulated stress responses in healthy volunteers. Immersive VR experiences altered physiological and psychological stress markers, including cortisol levels and white blood cell counts.
Area of Science:
- Neuroscience
- Psychology
- Medical Technology
Background:
- Virtual reality (VR) offers immersive experiences with growing applications in medicine.
- VR's potential to reconfigure brain perception highlights its use in stress management.
- Understanding VR's physiological and psychological impact is crucial for stress regulation.
Purpose of the Study:
- To assess the physiological and psychological effects of stressful versus relaxing VR experiences.
- To explore VR's effectiveness in manipulating stress levels in healthy individuals.
- To investigate VR's impact on stress markers and immune response.
Main Methods:
- Pilot study with 20 healthy volunteers in a randomized cross-over design.
- Continuous measurement of physiological signals during VR exposure.
- Collection of blood samples and psychological test data pre- and post-VR experience.
Main Results:
- Physiological and psychological responses aligned with the VR experience's nature.
- Statistically significant differences in cortisol levels between Stress and Relax VR conditions.
- Significant changes in white blood cell counts post-Stress VR exposure.
Conclusions:
- VR scenarios can modulate individual stress levels and immune responses.
- This study provides initial evidence for VR's role in stress modulation.
- Future research may explore VR-based treatments for stress-related health issues.
