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Substrate-selective mTORC1 regulation and gene dosage-dependent tissue divergence in Birt-Hogg-Dubé syndrome

Zhi-Lie Cao1,2, Si-Cheng Zhao3, Feng Lin4

  • 1Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Enze Hospital of Hangzhou Medical College, Taizhou Enze Medical Center (Group), Taizhou, China.

Frontiers in Oncology
|August 6, 2026
PubMed

Keywords:
Birt-Hogg-Dubé syndromeFLCNTFEBhaploinsufficiencymTORC1renal cell carcinomasubstrate selectivity

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