Related Experiment Video

Updated: Aug 7, 2026

Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV
03:53

Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV

Published on: November 10, 2023

Epidemiological characteristics analysis of childhood influenza A virus infections in Hebei, China (2020-2024)

Yishuo Sun1, Mingzhe He2, Chan Wen1

  • 1Department of Medical, Hebei Province of Children's Hospital, Shijiazhuang, Hebei, China.

Frontiers in Pediatrics
|August 6, 2026
PubMed

Insights

Childhood influenza A virus infections in Hebei, China, show increasing rates and peak in winter. High co-infection rates highlight the need for targeted prevention in young children.

Area of Science:

  • Epidemiology
  • Virology
  • Public Health

Background:

  • Influenza A virus poses a significant threat to pediatric populations globally.
  • Understanding regional epidemiological patterns is crucial for effective public health interventions.

Purpose of the Study:

  • To analyze the epidemiological and infection characteristics of childhood influenza A virus in Hebei, China (2020-2024).
  • To provide a data-driven basis for optimizing influenza prevention and control strategies in children.

Main Methods:

  • Retrospective analysis of epidemiological and clinical data from hospitalized children with influenza A.
  • Nucleic acid extraction and multiplex PCR testing using the GeXP system for pathogen detection.

Main Results:

  • Over 298,000 specimens analyzed; 20.39% tested positive for influenza A.
  • Detection rates increased annually from 2020 to 2024, peaking in winter (29.04%).
  • Mixed infections (26.34%) were common, involving rhinovirus, RSV, and Mycoplasma pneumoniae.

Conclusions:

  • Pediatric influenza A in Hebei shows age clustering, strong seasonality, and high co-infection rates.
  • Targeted surveillance and protective measures for children aged 1-5, especially in winter, are recommended.
  • Findings support enhanced influenza prevention, control, and clinical management strategies.
Abstract

Keywords:
ChinaHebeichildrenepidemiologyinfection characteristicsinfluenza A virus

More Related Videos

Influenza Virus Propagation in Embryonated Chicken Eggs06:56

Influenza Virus Propagation in Embryonated Chicken Eggs

Published on: March 19, 2015

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses08:10

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

Published on: January 15, 2020

Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
Vaccinations01:51

Vaccinations

Overview
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...