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Case Report: Early T-cell precursor acute lymphoblastic leukemia with aberrant CD19 expression and an NPM1 mutation

Yan Lu1, Yiran Chen2, Qiaohong Zhang1

  • 1Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, China.

Frontiers in Oncology
|August 6, 2026
PubMed
Summary

This case report details the first instance of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) with a nucleophosmin 1 (NPM1) mutation. This rare finding, alongside aberrant CD19 expression, presents diagnostic challenges in leukemia.

Keywords:
ETP−ALLFLT3−ITDNPM1 mutationflow cytometrynext−generation sequencing

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