Related Experiment Video
Updated: Aug 7, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Compound Chamomile and Lidocaine Hydrochloride Gel in Oral Diseases: A Review of Current Evidence and Potential
Zhongli Wang1, Xuelian Zeng1, Yingli Song1
1Department of Stomatology, Shapingba Hospital affiliated to Chongqing University, Chongqing, People's Republic of China.
Abstract:
Oral diseases frequently entail microbial infections or mucosal damage, typically accompanied by pain and discomfort. Present pharmaceutical interventions for oral conditions in clinical settings are constrained by their singular therapeutic effects, insufficient pain relief, and practical inconveniences. The exploration of novel compound medications holds promise for augmenting clinical treatment outcomes. Compound chamomile and lidocaine hydrochloride gel (CCLHG) represents a composite formulation endowed with analgesic, anti-inflammatory, and wound healing properties, showcasing auspicious potential in oral disease management. This article summarizes the articles of CCLHG in treating various oral diseases. Electronic databases PubMed, Embase, Web of Science, Cochrane Library, Wangfang, China National Knowledge Infrastructure and China Science and Technology Journal Database were searched from inception to August 30, 2025. A total of 1413 articles were searched. 27 articles were finally included. Our analysis reveals preliminary therapeutic potential of CCLHG in managing periodontal diseases, oral mucosal conditions, pericoronitis, dry socket syndrome, peri-implantitis, and related maladies. However, given the overall limited sample sizes, variability in methodology, and generally moderate-to-low quality of the included studies, these findings warrant caution. Further high-quality investigations are therefore essential to substantiate its clinical utility.
Related Concept Videos
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Chemistry and Structure-Activity Relationship
Local Anesthetics: Mechanism of Action
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...