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Current Status of Immunotherapy in Resectable Lung Cancer
Paulami Deshmukh1, Omar Abughanimeh2, Apar Kishor Ganti2,3
1Department of Medicine, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra India.
Indian Journal of Surgical Oncology
|August 6, 2026
Summary
Immunotherapy is revolutionizing lung cancer treatment, improving outcomes for non-small cell lung cancer (NSCLC) when combined with surgery. This approach requires careful planning and multidisciplinary care for optimal results.
Area of Science:
- Oncology
- Surgical Oncology
- Immunotherapy
Background:
- Lung cancer is a leading cause of cancer mortality globally, with suboptimal outcomes in advanced stages.
- While immunotherapy has advanced metastatic treatment, its role is expanding into perioperative settings for resectable non-small cell lung cancer (NSCLC).
Purpose of the Study:
- To review current evidence on immunotherapy in lung cancer, focusing on surgical implications.
- To explore the integration of immunotherapy into surgical oncology and its impact on patient care.
Main Methods:
- Critical examination of pivotal clinical trials (IMpower010, CheckMate 816, KEYNOTE-091).
- Analysis of emerging immunotherapy modalities and their surgical relevance.
- Review of challenges and opportunities in multidisciplinary management.
Main Results:
- Pivotal trials show immunotherapy significantly improves outcomes in perioperative NSCLC management.
- Immunotherapy integration necessitates adjustments in operative planning, toxicity management, and coordination.
Conclusions:
- Immunotherapy combined with surgery marks a significant advancement in lung cancer treatment, offering improved outcomes.
- This integration presents challenges in patient selection, timing, and multidisciplinary care, particularly relevant for India's rising lung cancer burden.
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