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Updated: Aug 7, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

Correction: GWAS analysis of a depression cohort defined by an EHR-phenotyping algorithm reveals the role of immune

Su Xian1, David Carrell2, Jordan W Smoller3,4

  • 1Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, United States.

Frontiers in Genetics
|August 6, 2026
PubMed

Keywords:
EHR (electronic health record)GWASdepressiongeneticsimmune regulationphenotyping algorithms

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...