Molecularly imprinted nanocomposite sensor for sensitive and selective electrochemical detection of sunitinib

For the sensitive and selective detection of sunitinib (STB), a new electrochemical sensor based on the molecularly imprinted polymer poly(o-phenylenediamine) (PoPD) has been created. Sunitinib was included as the template molecule during the electropolymerization with o-PD on a modified electrode made of copper nanoparticles and multiwalled carbon nanotubes to create the sensor. The modified electrode's surface was stripped of the template molecules using a 0.1 M phosphate buffer (PB) solution in order to create the molecularly imprinted polymer (MIP). Electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) were used to analyze the imprinted layer. Sunitinib concentration, the total number of CV cycles utilized by the electropolymerization process, the extraction of template solution from the imprinted film, and the duration of incubation were all optimized for the sensor's fabrication. The improved STB-MIP/MWCNTs-CuNPs@SPCE has been studied using scanning electron microscopy (SEM) and cyclic voltammetry (CV) using [Fe(CN)₆]^3-/4- as a redox probe. Following optimization, STB was found in standard solutions using differential pulse voltammetry (DPV) within a linear range of 20 to 280 µM. The sensor produced good results when used to measure the quantity of sunitinib in human serum samples with good reproducibility.