Multidimensional Exploration of Platinum Complexes for Cancer Therapy

Area of Science:

• Medicinal Chemistry
• Oncology
• Drug Discovery

Background:

• Platinum complexes are crucial in cancer therapy.
• Current designs target hallmarks of cancer like TME and metabolism.
• Evolution towards multi-target drugs is observed.

Purpose of the Study:

• To review novel platinum complexes designed for improved efficacy and reduced side effects.
• To highlight advancements in platinum-based cancer drug development since 2020.
• To explore multimodal platinum complexes integrating various therapeutic modalities.

Main Methods:

• Literature review of platinum complexes published since 2020.
• Analysis of mechanisms targeting cancer hallmarks and immune cells.
• Categorization of complexes based on therapeutic strategies (chemotherapy, immunotherapy, PDT, SDT, radiotherapy).

Main Results:

• Platinum complexes are transitioning to multitarget agents.
• Novel designs address resistance, metabolism, angiogenesis, metastasis, and TME.
• Multimodal complexes offer synergistic and precise cancer treatment options.

Conclusions:

• Platinum-based anticancer drugs are diversifying with advanced mechanisms.
• New complexes show potential for enhanced therapeutic efficacy and minimized toxicity.
• The field is rapidly evolving towards multifunctional and targeted therapies.