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Topological Densification-Reinforced Robust and Durable Protein Adhesive at Dynamic Interfaces
Xianjia Lin1, Shuai Chen1, Bo Li2
1School of Chemistry and Molecular Engineering, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, P. R. China.
Angewandte Chemie (International Ed. in English)
|August 6, 2026
Summary
This study introduces a novel bioadhesive using a topological densification strategy. This advanced protein-based sealant achieves robust wet tissue adhesion, outperforming existing clinical options for surgical applications.
Area of Science:
- Biomaterials Engineering
- Surgical Innovation
- Polymer Chemistry
Background:
- Durable adhesion is critical for surgical sealants and hemostasis.
- Existing biomimetic adhesives struggle with high-velocity blood flow and complex application.
- Need for advanced bioadhesives in demanding surgical settings.
Purpose of the Study:
- To develop a strong and durable bioadhesive using a topological densification strategy.
- To overcome limitations of current tissue sealants in challenging surgical conditions.
- To engineer a versatile platform for high-performance surgical adhesives.
Main Methods:
- Crosslinking a lysine-rich elastin-like protein with an ortho-phthalaldehyde-grafted crosslinker.
- Utilizing rapid covalent bonding to form a dense protein topological network.
- Employing a topological densification strategy to enhance adhesion and reduce hydration.
Main Results:
- Achieved exceptional wet tissue adhesion strength of approximately 252 kPa.
- Demonstrated clamp-free sealing of high-pressure arterial hemorrhage in large animals.
- Successfully performed safe dural repair in confined spaces without nerve compression risk.
Conclusions:
- The developed bioadhesive offers superior strength and durability compared to existing sealants.
- The topological densification strategy provides a versatile design principle for advanced bioadhesives.
- This platform is suitable for demanding surgical applications requiring robust tissue sealing and hemostasis.
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