Streamlining Cancer Reporting: CAP eCC Template Integration and Data Management

Area of Science:

• Oncology
• Bioinformatics
• Health Informatics

Background:

• Cancer impacts military readiness, affecting over 1,000 active-duty personnel annually.
• The Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) Consortium aims to improve cancer research and care.
• Integrating College of American Pathologists (CAP) electronic Cancer Checklists (eCC) is challenging for institutions.

Purpose of the Study:

• To develop a software system for automating CAP eCC template integration within the APOLLO Consortium.
• To streamline data management for cancer research and enhance force readiness.
• To create AI-ready, CAP-compliant datasets for precision oncology.

Main Methods:

• Developed eCC2Db software to automate parsing of CAP eCC XML templates.
• Generated Oracle database objects and metadata for eCC forms.
• Integrated eCC2Db with the Data Tracking System for APOLLO (DTS-APOLLO) for interactive form completion and data management.

Main Results:

• Eliminated manual database design and reduced transcription errors.
• Improved compliance with CAP standards and demonstrated scalability.
• Implemented 134 CAP eCC templates, including 117 organ and 17 biomarker templates, covering most CAP protocols.

Conclusions:

• The DTS-APOLLO system, powered by eCC2Db, significantly strengthens APOLLO's data infrastructure.
• Automated eCC management enhances military readiness and supports precision oncology.
• The system produces AI-ready datasets crucial for predictive analytics and treatment decision support.