NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Infectious Diseases

Background:

• Multidrug-resistant bacteria and biofilms pose significant challenges to conventional antibiotics.
• Near-infrared (NIR) photothermal therapy (PTT) and photodynamic therapy (PDT) offer non-antibiotic alternatives.
• Single-modality NIR therapies have limitations in efficacy and potential tissue damage.

Purpose of the Study:

• To provide a comprehensive review of NIR-mediated multimodal antibacterial strategies.
• To explore the synergistic effects of combining PTT/PDT with other therapies.
• To discuss advancements in overcoming antibiotic resistance and biofilm formation.

Main Methods:

• Review of recent scientific literature on NIR-mediated synergistic antibacterial therapies.
• Focus on combinations including gas therapy (GT), chemodynamic therapy (CDT), immunotherapy, antibiotic adjuvants, and sonodynamic therapy (SDT).
• Analysis of mechanisms for overcoming resistance, disrupting biofilms, and enhancing antibacterial effects.

Main Results:

• NIR-mediated multimodal strategies demonstrate synergistic antimicrobial effects.
• Combined therapies effectively overcome multidrug resistance and disrupt biofilms.
• These approaches show potential for enhanced antibacterial efficiency and wound healing.

Conclusions:

• NIR-mediated multimodal therapies represent a promising avenue for combating bacterial infections.
• Further research is needed to address challenges for clinical translation.
• These strategies offer hope for overcoming the limitations of traditional antibiotics.