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Updated: Aug 8, 2026

Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
Generation of an induced pluripotent stem cell line (HMSCATi007-A) from an epileptic patient with DEPDC5 gene
Xinwei Li1, Zuo Chunyan1, Mengcao Lu1
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Abstract:
Familial Focal Epilepsy with Variable Foci 1 (FFEVF1) is an autosomal dominant epilepsy disorder characterized by focal seizures. Induced pluripotent stem cells (iPSCs) were derived from a 21-year-old epileptic patient carrying a heterozygous DEPDC5 c.2748 (C > G) (exon 29) variant. The derived iPSCs maintain a normal karyotype, express pluripotency markers, and retain the ability to differentiate into the three germ layers. iPSCs are for research use only, including scientific research and the development of anti-epileptic therapeutics.
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