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Updated: Aug 8, 2026
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Wound healing prediction algorithm based on real-world data and validation for the effect of platelet-rich plasma on
Peng Zhao1, Nan Zhang1, Zhensheng Ma1
1Department of Orthopaedics, Tangshan Kailuan General Hospital, Tangshan, Hebei Province, China.
Aims:
To develop a wound-healing prediction algorithm and validate the effect of platelet-rich plasma (PRP) gel for treating elderly diabetic foot ulcer (DFU) patients.
Method:
From April 2020 to April 2022, 68 patients with Wagner Grade II-III DFU were consecutively enrolled, and their demographic, clinical, laboratory, and follow-up data were collected. A multiple regression model was used to develop a wound-healing algorithm with subsequent graphic model-fitting analysis. In the subgroup analysis, this study further compared the hemoglobin levels, inflammation indicators, and cytokines between the PRP treatment group (N = 31) and the non-PRP treatment group (N = 37). A wound healing prediction algorithm was developed as follows: Wound Healing Time (WHT) = -1.38 - 1.799 × PRP treatment + 0.813 × IL-6 - 0.158 × HbA1C + 0.559 × previous ulcer duration.
Results:
In this prediction algorithm, the application of PRP treatment was identified as a significant parameter influencing WHT. In further subgroup analysis, the PRP treatment group showed superior results in terms of white blood cells, blood sedimentation, C-reactive protein, VEGF, and ENA-78 levels (all P-value < 0.01) compared with the non-PRP treatment group.
Conclusion:
PRP treatment promoted wound healing in elderly DFU patients by modulating inflammation and enhancing tissue regeneration, and the proposed algorithm offered predictive utility for healing time.
