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Updated: Aug 8, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
Published on: November 29, 2013
Capturing molecular handshakes: PhIX-MS reveals transient interactions that control the proteasome complex
1Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Abstract:
In this issue of Molecular Cell, Lee et al.1 address a central structural biology challenge: capturing low-affinity protein interactions in cells and integrating the resulting restraints with cryoelectron microscopy and AlphaFold to localize dynamic interactors on native human proteasomes.
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