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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Targeting cancer epigenetic pathways with small-molecule modulators for potential therapeutic purposes

Peng Jin1, Yi Wang2, Na Zhao3

  • 1Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110001, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|August 6, 2026
PubMed
Summary

Epigenetic therapies, targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes, show promise in cancer treatment by altering gene expression. Further research is needed to address safety and clinical translation challenges for these novel epigenetic drugs.

Keywords:
Epigenetic regulatorsSmall-molecule compoundscancer therapy

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