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ECM-Derived Biomimetic Adhesive Patch Regulating the Inflammatory Microenvironment to Accelerate Oral Ulcer Healing
Qiu-Shuang Cheng1, Sheng-Chang Luo2, Kai Fan1
1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian 361021, P. R. China; Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, Fujian 361021, P. R. China.
A new biomimetic bilayer patch effectively manages oral ulcers by mimicking native mucosa. This engineered patch promotes tissue regeneration and resolves inflammation, offering a promising strategy for improved oral ulcer treatment.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Oral Medicine
Background:
- Oral ulcers present management challenges due to the moist oral environment and persistent inflammation.
- Existing treatments are limited in addressing the complex oral ulcer microenvironment.
Purpose of the Study:
- To engineer a biomimetic bilayer patch for effective oral ulcer management.
- To achieve immune modulation and synergistic tissue regeneration for oral ulcers.
Main Methods:
- Developed a bilayer patch with a bioadhesive inner layer (dopamine-modified esophageal mucosa decellularized extracellular matrix and hyaluronic acid methacrylate loaded with dexamethasone) and a hydrophobic ethylcellulose backing.
- Investigated wet adhesion properties in a moist environment.
- Assessed the patch's ability to modulate inflammatory signaling (JAK-STAT) and antioxidant networks in macrophages.
- Evaluated efficacy in a rat oral ulcer model.
Main Results:
- The patch demonstrated robust wet adhesion, adhering effectively in moist conditions.
- The patch successfully reprogrammed the inflammatory milieu by modulating JAK-STAT signaling and antioxidant networks.
- In vivo studies showed accelerated re-epithelialization and functional recovery compared to commercial products.
Conclusions:
- The developed mucosa-inspired bilayer patch offers a promising strategy for oral ulcer management.
- The patch's design facilitates immune modulation and tissue regeneration.
- This ECM-derived platform presents a translatable biomaterial approach for improving oral ulcer treatment and broader tissue engineering applications.
