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Updated: Aug 8, 2026
12:04
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
Published on: December 9, 2022
Factors Associated With Accelerated Fracture Healing in Patients With Traumatic Brain Injury and Extremity Comminuted
Xueqian Li1, Rongrong Cao2, Cheng Wang1
1Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China.
Orthopaedic Surgery
|August 6, 2026
Summary
Younger age and more severe traumatic brain injury (TBI), indicated by a lower Glasgow Coma Scale (GCS) score, predict faster bone healing in patients with comminuted fractures. This finding aids in identifying patients with high healing potential.
Area of Science:
- Orthopedics
- Traumatology
- Neuroscience
Background:
- Traumatic brain injury (TBI) is clinically linked to accelerated bone healing, but the underlying factors are unclear.
- Previous research on TBI's effect on fracture healing has yielded conflicting results.
- Understanding these factors is crucial for optimizing treatment in patients with concurrent TBI and fractures.
Purpose of the Study:
- To identify clinical factors associated with accelerated fracture healing in patients with TBI and comminuted limb fractures.
- To provide an evidence-based foundation for understanding TBI-promoted fracture healing.
- To aid in early identification of patients with enhanced healing potential.
Main Methods:
- Retrospective case-control study of 119 patients with TBI and comminuted fractures (Jan 2020-Apr 2024).
- Patients categorized into accelerated healing (AHG) and normal/delayed healing (NDHG) groups based on radiographic scores.
- Analysis included demographics, TBI severity (GCS score), laboratory indices, fracture conditions, and functional outcomes (SMFA); logistic regression and ROC curves used for analysis.
Main Results:
- Younger age and lower Glasgow Coma Scale (GCS) scores (indicating more severe TBI) were independent predictors of accelerated fracture healing.
- Multivariate analysis showed younger age (OR=0.875) and lower GCS score (OR=0.490) significantly predicted accelerated healing.
- ROC curve analysis demonstrated strong predictive values for age (AUC=0.893) and GCS score (AUC=0.851).
Conclusions:
- In patients with TBI and comminuted fractures, younger age and greater TBI severity (lower GCS score) independently predict accelerated bone healing.
- These findings help clinicians identify patients with high healing potential for optimized treatment strategies.
- The results offer insights into the neurohumoral regulation of bone regeneration and guide further research.
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