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Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-Endodontic Treatment Pain: A Randomised Controlled Trial
Hafsa Zaki1, Shahbaz Ahmed Jat1, Fazal-Ur-Rehman Qazi1
1Department of Operative Dentistry and Endodontics, Dr Ishrat-ul-Ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi, Pakistan.
Summary
Trypsin-chymotrypsin effectively managed post-endodontic pain, showing comparable efficacy to naproxen sodium. While pain scores were similar initially, trypsin-chymotrypsin demonstrated a significant reduction in pain at 6 hours.
Area of Science:
- Dentistry
- Pharmacology
Background:
- Postoperative pain is a common concern following endodontic treatment.
- Non-steroidal anti-inflammatory agents (NSAIDs) are frequently used to manage this pain.
- Trypsin-chymotrypsin presents an alternative enzymatic approach for pain management.
Purpose of the Study:
- To compare the efficacy of trypsin-chymotrypsin versus naproxen sodium in alleviating post-endodontic pain.
- To evaluate and compare mean pain scores using the numeric rating scale (NRS) at various time intervals.
Main Methods:
- A randomized controlled trial involving 100 patients undergoing endodontic treatment.
- Patients were allocated to receive either trypsin-chymotrypsin (n=50) or naproxen sodium (n=50).
- Pain was assessed using the NRS at 1, 6, 12, and 24 hours post-treatment; statistical analysis included Mann-Whitney U, independent-sample t-tests, and chi-square tests.
Main Results:
- No significant differences in baseline characteristics or pre-operative pain between groups (p >0.05).
- Comparable pain scores at 1-hour post-treatment (p = 0.695).
- Trypsin-chymotrypsin showed significantly lower pain scores at 6 hours (p = 0.049) compared to naproxen sodium; both groups reported zero pain at 12 and 24 hours (p = 0.999).
Conclusions:
- Trypsin-chymotrypsin demonstrates comparable efficacy to naproxen sodium in managing post-endodontic pain.
- The findings suggest trypsin-chymotrypsin is a viable option for pain relief in teeth with symptomatic irreversible pulpitis.
