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Frequency of Crescentic Glomerulonephritis in Adults Presenting with Acute Kidney Injury

Bushra Sikandar1, Mubarak Mohammad2, Aiyesha Humaira1

  • 1Department of Pathology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|August 7, 2026
PubMed

Insights

Crescentic glomerulonephritis (CRGN) affects 8% of adults with acute kidney injury (AKI). This study highlights the low but significant prevalence of CRGN in Pakistan, emphasizing the need for increased clinical awareness and diagnostic vigilance for AKI patients.

Area of Science:

  • Nephrology
  • Pathology
  • Internal Medicine

Background:

  • Acute kidney injury (AKI) is a critical clinical syndrome.
  • Crescentic glomerulonephritis (CRGN) is a severe form of glomerular disease.
  • Understanding the frequency of CRGN in AKI is essential for patient management.

Purpose of the Study:

  • To determine the frequency of crescentic glomerulonephritis (CRGN) in adults presenting with acute kidney injury (AKI).
  • To apply the latest Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for AKI definition.
  • To provide insights into the burden of CRGN in a developing country context.

Main Methods:

  • A cross-sectional observational study was conducted.
  • 152 adult patients with AKI undergoing renal biopsy were included.
  • Data on demographics, clinical presentation, and laboratory findings (serum creatinine, serum urea) were collected and analyzed.

Main Results:

  • The prevalence of CRGN among adult AKI patients was 8% (n=12).
  • Acute tubular injury (36.8%) and cortical infarction (17.8%) were more common findings.
  • No significant differences in CRGN frequency were observed based on age, gender, serum urea, or serum creatinine levels.

Conclusions:

  • A low but significant prevalence of CRGN (8%) was found in adult AKI patients.
  • This finding underscores the importance of clinical awareness and diagnostic vigilance for CRGN in Pakistan.
  • Further research may be needed to explore specific risk factors and management strategies for CRGN in this population.
Abstract

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