Related Experiment Videos

The C-Reactive Protein-Triglyceride Glucose Index and Incidence of Cardiovascular Disease Among Individuals with

Yin Wang1, Jie Luo1, Zhaofu Tan2

  • 1Postdoctoral Research Station , Bishan Hospital of Chongqing Medical University, Chongqing, China.

Endocrinology and Metabolism (Seoul, Korea)
|August 7, 2026
PubMed

Insights

The C-reactive protein-triglyceride glucose index (CTI) is linked to higher cardiovascular disease risks in hypertensive individuals. Elevated CTI predicts increased chances of coronary heart disease, stroke, atrial fibrillation, and heart failure.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Hypertension Management

Background:

  • The C-reactive protein-triglyceride glucose index (CTI) combines inflammation and insulin resistance markers.
  • Its association with cardiovascular disease (CVD) risk in hypertensive patients is not well-established.

Purpose of the Study:

  • To investigate the relationship between CTI and incident CVD events in individuals with hypertension.
  • To assess CTI as a potential predictive biomarker for CVD in this population.

Main Methods:

  • Longitudinal analysis of 168,186 UK Biobank participants.
  • Cox proportional hazards regression to evaluate associations between CTI and incident coronary heart disease (CHD), atrial fibrillation (AF), heart failure (HF), and stroke.
  • Subgroup and sensitivity analyses were conducted to confirm findings.

Main Results:

  • CTI demonstrated significant positive linear associations with incident CHD and stroke.
  • Nonlinear associations were found between CTI and incident AF and HF.
  • Elevated CTI levels were robustly linked to increased risks for all assessed CVD outcomes.

Conclusions:

  • The CTI is a promising predictive marker for cardiovascular disease in individuals with hypertension.
  • Higher CTI levels correlate with increased risks of major cardiovascular events, including CHD, AF, HF, and stroke.
Abstract

Keywords:
C-reactive protein-triglyceride glucose indexCardiovascular diseasesCohort studiesHypertensionUK Biobank

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...