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Updated: Aug 8, 2026
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
Published on: November 24, 2017
Preserved Limbic White Matter Predicts Favorable 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy
Xingyu Chen1,2, Shuhei Tomoshige1, Ria Wright3
1The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA.
Objective:
Accurate prediction of both favorable and unfavorable long-term neurodevelopmental outcomes of neonatal hypoxic-ischemic encephalopathy (HIE) is essential for clinical care, yet the brain structures underlying a favorable prognosis remain unclear. This study aimed to identify diffusion magnetic resonance imaging (MRI) measures that can predict the 2-year outcomes in neonates with HIE.
Methods:
We analyzed whole-brain diffusion MRI scans from a retrospective cohort of 40 neonates with HIE, acquired within 14 days of birth. Diffusion measures were quantified across 16 cerebrum regions covering the whole cerebrum. We used the area under the Receiver Operating Characteristic curve (AUC) to evaluate the performance of regional fractional anisotropy (FA) and mean diffusivity (MD) values in predicting neurodevelopmental outcomes assessed at 2 years of age.
Results:
Reduced FA in the thalamus (AUC = 0.990), basal ganglia (AUC = 0.961), basal forebrain (AUC = 0.951), and limbic white matter (AUC = 0.961) strongly predicted severe disability or death, whereas preserved limbic white matter FA uniquely predicted favorable outcomes (AUC = 0.811).
Conclusion:
While FA reduction in the thalamus, basal ganglia, and basal forebrain is a robust marker for severe outcomes, the limbic white matter demonstrated sensitivity to mild hypoxic-ischemic injury. Therefore, the preservation can be a potential marker for predicting favorable neurodevelopmental trajectories.
