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Updated: Aug 8, 2026
03:13
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Research advances on acute kidney injury and brain dysfunction
Min Li1, Xiaohui Liao1, Jingyang Ran1
1Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Nephrology
|August 7, 2026
Summary
Acute kidney injury (AKI) can lead to brain dysfunction and cognitive impairment due to insulin resistance (IR). Early prediction models and targeted therapies may improve outcomes for patients with AKI-related brain issues.
Area of Science:
- Nephrology
- Neurology
- Metabolic Disorders
Background:
- Acute kidney injury (AKI) is a critical condition with significant multisystem complications.
- Renal-brain axis dysfunction, including cognitive impairment, is a recognized complication of AKI.
- Insulin resistance (IR) is increasingly recognized as prevalent in AKI and linked to its progression.
Purpose of the Study:
- To discuss the specific role of insulin resistance in AKI-induced cognitive impairment.
- To highlight the potential of multimodal neuroimaging and machine learning for early risk prediction.
- To explore therapeutic strategies for ameliorating AKI-associated brain dysfunction.
Main Methods:
- Review of current mechanistic investigations into AKI-associated brain dysfunction.
- Discussion of emerging evidence on the role of insulin resistance in AKI.
- Exploration of prospective applications of neuroimaging and machine learning.
- Elaboration on therapeutic potentials of anti-inflammatory strategies and natural compounds.
Main Results:
- AKI predisposes patients to significant brain dysfunction, including cognitive impairment, dementia, and depression.
- Insulin resistance is highly prevalent in AKI and correlates with its pathophysiology.
- Canonical pathways like inflammation, oxidative stress, and uremic toxins contribute to AKI-brain dysfunction.
Conclusions:
- Insulin resistance plays a crucial role in AKI-induced cognitive impairment.
- Combined neuroimaging and machine learning offer promise for early risk prediction models.
- Targeted anti-inflammatory strategies and natural compounds show therapeutic potential for AKI-associated brain dysfunction.
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