Related Experiment Videos
The correlation between serum progesterone levels and syringoma
Ifen Ayu Malinda1, Imam Budi Putra1, Ariyati Yosi1
1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Frontiers in Medicine
|August 7, 2026
Summary
This study found a significant correlation between elevated progesterone levels and syringoma, a benign skin tumor originating from eccrine glands. High progesterone may contribute to syringoma development, particularly in women.
Area of Science:
- Dermatology
- Endocrinology
- Oncology
Background:
- Syringoma is a benign adnexal tumor from eccrine glands, presenting as skin-colored papules, often periorbital.
- While not malignant, syringoma can cause cosmetic concerns and impact self-confidence.
- The exact cause of syringoma is unknown, but progesterone's role is suspected.
Purpose of the Study:
- To investigate the potential correlation between serum progesterone levels and the presence of syringoma.
- To explore hormonal influences on the development of eccrine gland tumors.
Main Methods:
- An observational, cross-sectional study involving 35 patients with syringoma and 35 controls.
- Dermatologic, dermoscopic examinations, and serum progesterone level assessment via ELISA.
- Data analyzed using Fisher's exact test.
Main Results:
- Syringoma most commonly affects women aged 26-35, with localized forms being most prevalent.
- Elevated serum progesterone levels were found in 28.57% of syringoma patients versus 5.71% of controls.
- A statistically significant positive correlation was observed between high progesterone levels and syringoma (OR 6.6, p=0.023).
Conclusions:
- Syringoma predominantly affects young to mid-adult women, with localized and familial forms noted.
- Elevated progesterone levels show a strong association with syringoma, suggesting hormonal involvement.
- Progesterone may influence syringoma development via effects on sweat glands and skin structures.
