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Renal Function and Quality of Life after the Mitrofanoff Procedure

M Rakhesh1, M M Zameer1, Vinay Chandrashekar1

  • 1Department of Pediatric Surgery, Narayana Health, Bengaluru, Karnataka, India.

Journal of Indian Association of Pediatric Surgeons
|August 7, 2026
PubMed

Insights

The Mitrofanoff procedure (MP) helps children with bladder dysfunction maintain kidney health and improve quality of life (QOL). Consistent clean intermittent catheterization (CIC) is key to preventing complications and preserving renal function.

Area of Science:

  • Pediatric Urology
  • Nephrology
  • Quality of Life Research

Background:

  • Bladder dysfunction in children can lead to recurrent urinary tract infections (UTIs), incontinence, and kidney damage.
  • The Mitrofanoff procedure (MP) enables clean intermittent catheterization (CIC), improving bladder emptying and reducing risks of renal impairment.
  • Long-term data on MP outcomes in developing countries are limited.

Purpose of the Study:

  • To evaluate mid- to long-term renal function and quality of life (QOL) in children following the Mitrofanoff procedure (MP).
  • To identify risk factors influencing renal and QOL outcomes after MP in a pediatric population.

Main Methods:

  • A retrospective longitudinal cohort study included 62 children who underwent MP between 2008 and 2023 with at least 6 months follow-up.
  • Evaluated renal function (eGFR, CKD staging), QOL (Pediatric Incontinence Questionnaire), continence, and CIC compliance.
  • Analyzed factors impacting renal outcomes.

Main Results:

  • Renal function remained stable or improved in 77.4% of patients; 93.5% experienced improved QOL.
  • Recurrent UTIs resolved in 35/45 affected children; social continence was achieved in 60 children.
  • CIC compliance (77.4%) was strongly associated with better renal outcomes.

Conclusions:

  • The Mitrofanoff procedure (MP), coupled with consistent clean intermittent catheterization (CIC), effectively preserves renal function and enhances QOL in children with bladder dysfunction.
  • Noncompliance with CIC and recurrent UTIs are significant risk factors for renal deterioration.
Abstract

Keywords:
Clean intermittent catheterizationMitrofanoff procedurequality of liferenal functions

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