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Atypical Neuroleptic Malignant Syndrome Without Hyperthermia: A Case Report
Abigael K Osena1, Palak A Fichadia1, Erick Melendez1
1Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Cureus
|August 7, 2026
Summary
Neuroleptic malignant syndrome (NMS) is a rare but serious side effect of antipsychotics. This case shows atypical NMS symptoms, emphasizing early recognition for better patient outcomes.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Neuroleptic malignant syndrome (NMS) is a rare, severe adverse reaction to antipsychotic medications.
- Classic NMS symptoms include hyperthermia, muscle rigidity, altered mental status, and autonomic instability.
- Atypical presentations of NMS, lacking some classic features, are increasingly reported, posing diagnostic challenges.