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Published on: September 27, 2024
Colorectal cancer screening in individuals with multiple sclerosis: A mixed-methods study
Chloé Pierret1, Romane Bouvier1, Sandrine Kerbrat2
1Rennes University, École des Hautes Etudes en Sante Publique, Rennes, France.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|August 7, 2026
Summary
Colorectal cancer screening (CCS) rates are similar in people with multiple sclerosis (pwMS) and the general population, but lower in older pwMS. Barriers include MS symptoms, while trust and awareness are facilitators.
Area of Science:
- Neurology
- Oncology
- Public Health
Background:
- People with multiple sclerosis (pwMS) report lower colorectal cancer risk, potentially due to reduced colorectal cancer screening (CCS) access.
- Understanding CCS disparities in pwMS is crucial for equitable cancer prevention.
Purpose of the Study:
- To compare CCS rates between pwMS and the general population.
- To identify barriers and facilitators influencing CCS uptake in pwMS using a mixed-methods approach.
Main Methods:
- A cohort study compared CCS coverage in 63,509 pwMS and 190,527 controls (aged 50-74) from 2022-2024.
- Multivariable models assessed factors associated with CCS in pwMS, complemented by qualitative interviews with 20 pwMS.
Main Results:
- Overall CCS coverage was comparable (41.2% in pwMS vs. 42.4% in controls).
- Older pwMS (≥65 years) had lower CCS rates, while younger pwMS (50-54 years) had higher rates.
- Barriers included MS-related motor/digestive symptoms and disgust; facilitators included health system trust and prevention awareness.
Conclusions:
- Colorectal cancer screening remains suboptimal for both pwMS and the general population.
- Older individuals with multiple sclerosis experience lower screening rates, highlighting a need for targeted interventions.
