Related Experiment Video
Updated: Aug 8, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Enantioselective Synthesis of Chiral Sulfoxides via Copper-Catalyzed Asymmetric Alkyne-Azide Cycloaddition
1Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Anhui Provincial Key Laboratory of Synthetic Chemistry and Applications, School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, Anhui235000, P. R. China.
Abstract:
Chiral sulfoxide scaffolds widely exist in biologically active natural products, drugs, ligands, and catalysts. The synthesis of this kind of molecule has received a considerable amount of attention. Herein, we report a highly enantioselective copper-catalyzed asymmetric alkyne-azide cycloaddition synthesis of chiral sulfoxides via desymmetrization. The practicality and attractiveness of this method are exhibited utilizing readily available starting materials, mild reaction conditions, good enantioselectivity, and a broad substrate scope.
Related Concept Videos
Preparation and Reactions of Sulfides
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Cycloaddition Reactions: Overview
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

