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Predicting early postoperative corneal edema after phacoemulsification: A retrospective observational study
Jing Fu1, Yanting Shi2, Yi Yang2
1Department of Ophthalmology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Medicine
|August 7, 2026
Summary
This study developed a prediction model for early corneal edema after phacoemulsification surgery. Factors like age, diabetes, and surgical complexity increase risk, aiding perioperative care.
Area of Science:
- Ophthalmology
- Surgical Outcomes
- Predictive Modeling
Background:
- Phacoemulsification is a common cataract surgery.
- Early postoperative corneal edema (EPCE) can affect visual recovery.
- Predicting EPCE risk is crucial for patient management.
Purpose of the Study:
- To develop and internally validate a multivariable prediction model for EPCE following phacoemulsification.
- To identify key patient-related and intraoperative factors associated with EPCE.
- To create a nomogram for individualized risk estimation.
Main Methods:
- Retrospective cohort study of 912 eyes undergoing phacoemulsification.
- EPCE defined by central corneal thickness increase or stromal haze.
- Multivariable logistic regression used for model development and validation.
Main Results:
- EPCE occurred in 15.1% of eyes.
- Predictors included older age, diabetes, lower endothelial cell density, and increased surgical complexity (nucleus hardness, operative duration, CDE, irrigation volume).
- Intraoperative events like anterior chamber instability and capsular/vitreous loss increased risk.
Conclusions:
- A validated prediction model incorporating systemic and intraoperative factors shows good discrimination and calibration for EPCE risk.
- The model may aid preliminary perioperative risk assessment.
- External validation is needed before routine clinical use.