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Updated: Aug 9, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
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Published on: May 31, 2018

PU.1 drives psoriasis pathogenesis by promoting intermediate monocytes-to-M1 macrophage differentiation through

Liping Jin1, Shiyao Pei2, Liang Dong3

  • 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, China; Furong Laboratory, Changsha, Hunan, 410008, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

Journal of Autoimmunity
|August 7, 2026
PubMed
Summary

The transcription factor PU.1 drives psoriasis inflammation by promoting intermediate monocyte differentiation. Inhibiting PU.1 with NHWD-870 shows promise for treating this skin condition.

Keywords:
BETDectin-1Intermediate monocytesM1 macrophagePU.1Psoriasis

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