Related Experiment Video
Updated: Aug 9, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
Published on: July 21, 2023
Maresin1 alleviates inflammation and improves extracellular matrix regeneration after intervertebral disc
Hui Wang1, Xiangyu Li2, Tao Yan3
1Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Zhejiang, China; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopedics, Wenzhou, China.
Abstract:
Intervertebral disc degeneration (IVDD) is characterized by excessive inflammation and extracellular matrix (ECM) degradation in the nucleus pulposus (NP), with limited current therapeutic options. Specialized pro-resolving mediators (SPMs) such as Maresin 1 (MaR1) have emerged as key regulators of inflammation resolution and tissue repair. Here, we report that MaR1 and its receptor LGR6 are significantly downregulated in degenerated human NP tissues, suggesting a loss of endogenous resolution capacity. Exogenous MaR1 administration effectively attenuated IL-1β-induced inflammation and ECM degradation in human NP cells and alleviated IVDD progression in rat models. Mechanistically, MaR1 simultaneously suppressed the catabolic AP-1/MMP pathway and activated the pro-anabolic OSR1/GDF7 axis, rebalancing ECM homeostasis. Notably, the therapeutic efficacy of MaR1 was completely abrogated in Lgr6-knockout mice, demonstrating that LGR6 is the indispensable mediator of MaR1's protective effects in vivo. Our findings identify the MaR1-LGR6 axis as a critical regulator of disc homeostasis and highlight MaR1 supplementation as a novel and promising strategy for IVDD treatment.
Related Concept Videos
Degenerative Disc Disease ll: Pathophysiology
Degenerative Disc Disease I: Introduction
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix
Herniated Intervertebral Disc l: Introduction
Role of Matrix Metalloproteases in Degradation of ECM
A...

