Related Experiment Video
Updated: Aug 9, 2026
Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors
Published on: January 31, 2025
Protein network on reticular heterostructure for competitive organic photoelectrochemical transistor biosensing
Bo-Han Kou1, Peiying Yin2, Miao-Hua Chen3
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry, Nanjing University, Nanjing, 210023, China; Zhejiang Key Laboratory of New Drug Development for Central Nervous System Diseases, Taizhou University, Zhejiang, 318000, China.
Abstract:
Synergizing reticular materials to form heterostructures has sparked increasing interest in diverse fields. Organic photoelectrochemical transistor (OPECT) has been demonstrated as a transformative platform for next-generation biosensors, optoelectronics, and neuromorphic simulation. Herein, covalent organic frameworks (COF)-on-hydrogen-bonded organic frameworks (HOF) heterojunction as a novel photogating module is first explored for competitive OPECT biosensing of streptomycin (STR) via a self-assembled protein network. The competitive binding by STR in the solution and on the surface can cause the variant coverage of protein network on the COF-on-HOF photogate, leading to the different steric hindrance with differentiable OPECT responses and thus achieving sensitive STR detection down to 0.5 pM. This work features competitive OPECT biosensing photogated by a reticular heterostructure.
