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Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
Published on: March 17, 2023
Designing a CCS That Focuses on Materials Transfer into Cleanrooms, BSCs, RABS, and Isolators: Poster Presented at
James N Polarine1, Mary Van Gaasbeck Carico2, Renee Buthe2
1STERIS jim_polarine@steris.com.
PDA Journal of Pharmaceutical Science and Technology
|August 7, 2026
Summary
Effective cleanroom contamination control requires robust decontamination of incoming materials. Vaporized hydrogen peroxide (VHP) is a highly effective method for eliminating fungal and bacterial spores, especially for sensitive items.
Area of Science:
- Microbiology
- Materials Science
- Environmental Health
Background:
- Materials transfer into cleanrooms presents a significant risk for introducing microbial contaminants like fungal and bacterial spores.
- Maintaining a sterile environment is critical for research, manufacturing, and healthcare applications within cleanrooms.
Purpose of the Study:
- To evaluate effective decontamination strategies for materials entering cleanroom environments.
- To highlight the benefits of vaporized hydrogen peroxide (VHP) for cleanroom material decontamination.
Main Methods:
- Review of existing decontamination protocols for cleanroom materials.
- Assessment of sporicide wiping/spraying techniques.
- Evaluation of vaporized hydrogen peroxide (VHP) pass-through chambers and room decontamination methods.
Main Results:
- Standard wiping or spraying with sporicide/disinfectant are common methods.
- Vaporized hydrogen peroxide (VHP) offers a highly effective alternative for decontamination.
- VHP demonstrates excellent material compatibility, making it suitable for sensitive items like electronics and soft metals.
Conclusions:
- Robust decontamination procedures are essential for effective cleanroom contamination control.
- Vaporized hydrogen peroxide (VHP) is a superior decontamination method for sensitive materials, ensuring both efficacy and material integrity.
