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Adapting Drug Delivery for High-Volume Home Administration: Poster Presented at PDA Week 2026
1Datwyler Healthcare yitian.xiao@datwyler.com.
PDA Journal of Pharmaceutical Science and Technology
|August 7, 2026
Summary
Biologics and sensitive therapeutics require larger subcutaneous injection volumes. New NeoFlex™ plungers and on-body injectors enable safe, self-administered, larger-volume SC drug delivery for patient-centric care.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Biotechnology
Background:
- The increasing use of biologics and sensitive therapeutics is changing subcutaneous (SC) drug delivery.
- SC administration supports patient self-administration and decentralized healthcare.
- Traditional SC injections are limited to low volumes (≤2mL) due to safety and tolerability concerns.
Purpose of the Study:
- To address the need for larger volume SC drug delivery solutions.
- To support the administration of higher doses for emerging therapies like monoclonal antibodies and anti-cancer treatments.
- To enable patient self-administration of increased SC volumes without compromising safety or efficacy.
Main Methods:
- Development of extended NeoFlex™ plungers for larger containers.
- Integration with novel on-body injectors for slow, controlled delivery.
- Collaborative development of container closure systems (CCS) and devices.
Main Results:
- Expanded feasible range of SC administration volumes.
- Enabled slow, controlled delivery of larger drug volumes via on-body injectors.
- Facilitated optimized, pre-verified platform solutions for faster market entry.
Conclusions:
- The new NeoFlex™ plungers and on-body injectors effectively expand SC administration volumes.
- This innovation supports the delivery of higher-dose therapeutics for patient self-administration.
- Collaborative development accelerates the availability of advanced SC drug delivery solutions to patients.
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