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A Noncanonical MET Exon 14 Splice-Site Variant in Pulmonary Sarcomatoid Carcinoma With Response to Capmatinib

Hyung-Joo Oh1,2, Yoo-Duk Choi2,3, Yoon-La Choi4

  • 1Division of Pulmonology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.

Thoracic Cancer
|August 7, 2026
PubMed

Insights

MET exon 14 skipping in non-small cell lung cancer (NSCLC) can be targeted with therapies. Noncanonical variants initially classified as VUS were confirmed to drive MET exon 14 skipping, enabling successful capmatinib treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MET exon 14 skipping is a key driver in non-small cell lung carcinoma (NSCLC).
  • Noncanonical splice-region variants are often misclassified as variants of unknown significance (VUS).
  • This misclassification can lead to missed treatment opportunities for NSCLC patients.
Keywords:
METcapmatinibcase reportsarcomatoid carcinoma

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